National Institute of Infectious Diseases “Raising concerns regarding pandemic potential of avian influenza A(H7N9)”

On 4/19/2013, National Institute of Infectious Diseases referred to the research of Eurosurveillance to report the raising concerns regarding the pandemic potential of avian influenza A(H7N9).

By 4/18/2013, 82 cases were reported and 17 people died. The institute states they can’t deny the possibility of the infection between humans. The secondary infection can take place by having an virus holder enter Japan.

The referred report is below,

Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.

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In conclusion, we here present a biological evaluation of the sequences of the avian influenza A(H7N9) viruses that caused fatal human infections in China. These viruses possess several characteristic features of mammalian influenza viruses, which are likely to contribute to their ability to infect humans and raise concerns regarding their pandemic potential.

 

Citation style for this article: Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M. Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill. 2013;18(15):pii=20453. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20453

Date of submission: 08 April 2013

 

 

http://www.nih.go.jp/niid/ja/diseases/a/flua-h7n9/2276-a-h7n9-niid/3477-riskassess-130418.html

http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20453

 

 

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Français :

L’Institut National des Maladies Infectieuses a “des inquiétudes quant au potentiel pandémique de la grippe aviaire  à H7N9”

 

Le 19 avril 2013, le National Institute of Infectious Diseases s’appuie sur les recherches d’Eurosurveillance pour alerter sur les inquiétudes grandissantes concernant le potentiel pandémique de la grippe aviaire A-H7N9.

Le 18 avril 2013, 82 cas sont enregistrés et 17 personnes en sont mortes. L’institut affirme qu’ils ne peuvent écarter la possibilité d’une infection entre les humains. L’infection secondaire peut se répandre à partir d’un porteur de virus entrant au Japon.

Le rapport en question dit ceci :

Au 10 avril 2013 et en Chine, le nouveau virus de la grippe de sous-type H7N9 a infecté 33 personnes et en a tué neuf. Leurs gènes de l’hémaglutinine (HA) et des neuramidases sont probablement issus de virus eurasiens des grippes aviaires ; Les autres gènes sont étroitement liés au virus H9N2 des grippes aviaires. Plusieurs caractéristiques des acides aminés changent pour le HA et la sous-unité d’ARN-polymérase Pb2, ce qui facilite probablement leur attache sur les récepteurs de type humain et leur réplication efficace dans les mammifères, respectivement, mettant en avant un potentiel pandémique pour ce nouveau virus.
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En conclusion, nous présentons ici une évaluation biologique des séquences du virus de la grippe aviaire  A(H7N9) qui sont à l’origine des infections humaines fatales de Chine. Ces virus possèdent plusieurs caractéristiques des virus de la grippe des mammifères, ce qui peut facilement contribuer à les aider à infecter les humains et suscite des inquiétudes quant à leur potentiel pandémique.

Référence bibiolographique : Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M. Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill. 2013;18(15):pii=20453. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20453

Date de soumission  : 08 avril 2013

http://www.nih.go.jp/niid/ja/diseases/a/flua-h7n9/2276-a-h7n9-niid/3477-riskassess-130418.html
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20453

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